Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

被引：279

作者：

Chamberlain, Marc C.

Glantz, Michael J.

Chalmers, Lisa

Van Horn, Alixis

Sloan, Andrew E.

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA

[2] Univ Massachusetts, Med Ctr, Dept Neurol & Oncol, Worcester, MA USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2007年 / 82卷 / 01期

关键词：

glioblastoma; temodar; radiotherpy;

D O I：

10.1007/s11060-006-9241-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.

引用

页码：81 / 83

页数：3

共 8 条

[1]

CROSS NE, 2003, COMPLICATIONS SYSTEM, P249

[2] RECURSIVE PARTITIONING ANALYSIS OF PROGNOSTIC FACTORS IN 3 RADIATION-THERAPY ONCOLOGY GROUP MALIGNANT GLIOMA TRIALS [J].

CURRAN, WJ ;

SCOTT, CB ;

HORTON, J ;

NELSON, JS ;

WEINSTEIN, AS ;

FISCHBACH, AJ ;

CHANG, CH ;

ROTMAN, M ;

ASBELL, SO ;

KRISCH, RE ;

NELSON, DF .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (09) :704-710

[3] Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression [J].

de Wit, MCY ;

de Bruin, HG ;

Eijkenboom, W ;

Smitt, PAES ;

van den Bent, MJ .

NEUROLOGY, 2004, 63 (03) :535-537

[4] Medical progress: Brain tumors [J].

DeAngelis, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (02) :114-123

[5] Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas [J].

Glantz, M ;

Chamberlain, M ;

Liu, Q ;

Litofsky, NS ;

Recht, LD .

CANCER, 2003, 97 (09) :2262-2266

[6]

Stewart JE, 2002, RADIOLOGY, V225, P337

[7] Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide [J].

Stupp, R ;

Dietrich, PY ;

Kraljevic, SO ;

Pica, A ;

Maillard, I ;

Maeder, P ;

Meuli, R ;

Janzer, R ;

Pizzolato, G ;

Miralbell, R ;

Porchet, F ;

Regli, L ;

de Tribolet, N ;

Mirimanoff, RO ;

Leyvraz, S .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (05) :1375-1382

[8] Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma [J].

Stupp, R ;

Mason, WP ;

van den Bent, MJ ;

Weller, M ;

Fisher, B ;

Taphoorn, MJB ;

Belanger, K ;

Brandes, AA ;

Marosi, C ;

Bogdahn, U ;

Curschmann, J ;

Janzer, RC ;

Ludwin, SK ;

Gorlia, T ;

Allgeier, A ;

Lacombe, D ;

Cairncross, JG ;

Eisenhauer, E ;

Mirimanoff, RO ;

Van Den Weyngaert, D ;

Kaendler, S ;

Krauseneck, P ;

Vinolas, N ;

Villa, S ;

Wurm, RE ;

Maillot, MHB ;

Spagnolli, F ;

Kantor, G ;

Malhaire, JP ;

Renard, L ;

De Witte, O ;

Scandolaro, L ;

Vecht, CJ ;

Maingon, P ;

Lutterbach, J ;

Kobierska, A ;

Bolla, M ;

Souchon, R ;

Mitine, C ;

Tzuk-Shina, T ;

Kuten, A ;

Haferkamp, G ;

de Greve, J ;

Priou, F ;

Menten, J ;

Rutten, I ;

Clavere, P ;

Malmstrom, A ;

Jancar, B ;

Newlands, E .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (10) :987-996

← 1 →