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Study of penetration of amphotericin B into cholesterol or ergosterol containing dipalmitoyl phosphatidylcholine Langmuir monolayers

被引：41
作者：
Dynarowicz-Latka, P
Seoane, R
Minones, J
Velo, M
Miñones, J
机构：
[1] Jagiellonian Univ, Fac Chem, Dept Gen Chem, PL-30060 Krakow, Poland
[2] Univ Santiago de Compostela, Dept Phys Chem, Fac Pharm, Santiago De Compostela 15706, Spain
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2003年 / 27卷 / 2-3期
关键词：
amphotericin B; Langmuir monolayers; lipid films; interactions; air-water interface;
D O I：
10.1016/S0927-7765(02)00099-1
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 [生物物理学];
摘要：
The interactions of amphotericin B (AmB) with sterols and phospholipids have been studied by adsorption of AmB from aqueous solutions into Langmuir monolayers from dipalmitoyl phosphatidylcholine (DPPC), ergosterol, cholesterol and their mixtures. The results show that AmB exhibits stronger interaction with cholesterol than ergosterol in one-component monolayers. However, for DPPC-sterol monolayers, the effectiveness of AmB penetration depends on the proportion of both film components in the mixed film as well as on the strength of interaction between DPPC and particular sterol. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：249 / 263
页数：15
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