NeuroCog FX: Computerized screening of cognitive functions in patients with epilepsy

被引：34

作者：

Hoppe, Christian ^{[1
]}

Fliessbach, Klaus ^{[1
]}

Schlegel, Uwe ^{[2
]}

Elger, Christian E. ^{[1
]}

Heimstaedter, Christoph ^{[1
]}

机构：

[1] Univ Bonn, Med Ctr, Dept Epileptol, D-53105 Bonn, Germany

[2] Ruhr Univ Bochum, Dept Neurol, Knappschaftskrankenhaus, Bochum, Germany

来源：

EPILEPSY & BEHAVIOR | 2009年 / 16卷 / 02期

关键词：

Epilepsy; Cognition; Memory; Computer-based testing; DOUBLE-BLIND; TEST BATTERY; MEMORY; DISEASE; PERFORMANCE; DEMENTIA; DEFICITS;

D O I：

10.1016/j.yebeh.2009.07.041

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

NeuroCog FX, a computerized neuropsychological screening instrument for serial examinations of patients with epilepsy and other neurological diseases, was developed to fill the gap between unspecific ratings and comprehensive assessments. Eight subtests address attention, working memory, verbal and figural memory, and language. The test duration is less than 30 min, In research contexts, the test can be applied at multiple sites by nonacademic personnel. Normative data were recorded from healthy subjects (N = 244, age range = 16-75 years; retest: N = 44; validation: N = 40) and unselected patients from an epileptology unit (N = 212; retest: N = 94; validation: N = 126). Psychometric analyses confirmed sufficient reliability and concurrent validity, particularly in patients. NeuroCog FX memory and overall performance scores showed "fair" to "good" diagnostic utility with respect to deficits revealed by established tests. NeuroCog FX provides reliable and valid measures of cognitive performance and may be used in clinical and research contexts as a screening instrument. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：298 / 310

页数：13

共 39 条

[1]

COGNITIVE SIDE-EFFECTS OF PHENYTOIN COMPARED WITH CARBAMAZEPINE IN PATIENTS WITH LOCALIZATION-RELATED EPILEPSY [J].

ALDENKAMP, AP ;

ALPHERTS, WCJ ;

DIEPMAN, L ;

VANTSLOT, B ;

OVERWEG, J ;

VERMEULEN, J .

EPILEPSY RESEARCH, 1994, 19 (01) :37-43

[2]

Aldenkamp AP, 2000, NEUROLOGY, V54, P271

[3]

BLEIBERG J, 1993, NEUROPSY NEUROPSY BE, V6, P245

[4]

Commission on European affairs: Appropriate standards of epilepsy care across Europe [J].

Brodie, MJ ;

Shorvon, SD ;

Canger, R ;

Halasz, P ;

Johannessen, S ;

Thompson, P ;

Wieser, HG ;

Wolf, P .

EPILEPSIA, 1997, 38 (11) :1245-1250

[5]

Sources of error in computerized neuropsychological assessment [J].

Cernich, Alison N. ;

Brennana, David M. ;

Barker, Linsey M. ;

Bleiberg, Joseph .

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2007, 22 (01) :S39-S48

[6]

Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users [J].

Chang, L ;

Ernst, T ;

Speck, O ;

Patel, H ;

DeSilva, M ;

Leonido-Yee, M ;

Miller, EN .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2002, 114 (02) :65-79

[7]

Development and validation of a test battery to assess subtle neurodevelopmental differences in children [J].

Davidson, Philip W. ;

Weiss, Bernard ;

Beck, Christopher ;

Cory-Slechta, Deborah A. ;

Orlando, Mark ;

Loiselle, David ;

Young, Edna Carter ;

Sloane-Reeves, Jean ;

Myers, Gary J. .

NEUROTOXICOLOGY, 2006, 27 (06) :951-969

[8]

Premorbid brain size is a determinant of functional reserve in abstinent crack-cocaine and crack-cocaine-alcohol-dependent adults [J].

Di Sclafani, V ;

Clark, HW ;

Tolou-Shams, M ;

Bloomer, CW ;

Salas, GA ;

Norman, D ;

Fein, G .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 1998, 4 (06) :559-565

[9]

Chronic epilepsy and cognition [J].

Elger, CE ;

Helmstaedter, C ;

Kurthen, M .

LANCET NEUROLOGY, 2004, 3 (11) :663-672

[10]

Computerized cognitive testing in patients with type I Gaucher disease: Effects of enzyme replacement and substrate reduction [J].

Elstein, D ;

Guedalia, J ;

Doniger, GM ;

Simon, ES ;

Antebi, V ;

Arnon, Y ;

Zimran, A .

GENETICS IN MEDICINE, 2005, 7 (02) :124-130

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