Microparticles and nanoparticles for drug delivery

被引：379

作者：

Kohane, Daniel S. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Lab Biomat & Drug Delivery, Div Crit Pediat Care, Boston, MA 02114 USA

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 2007年 / 96卷 / 02期

关键词：

biocompatibility; local delivery; systemic delivery; toxicity; PROTEIN-SUGAR PARTICLES; LARGE POROUS PARTICLES; IN-VIVO; LIPOSOMES; BUPIVACAINE; RELEASE; MICROSPHERES; CELLS; RAT;

D O I：

10.1002/bit.21301

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Particulate drug delivery systems have become important in experimental pharmaceutics and clinical medicine. The distinction is often made between micro- and nanoparticles, being particles with dimensions best described in micrometers and nanometers respectively. That size difference entails real differences at many levels, from formulation to in vivo usage. Here I will discuss those differences and provide examples of applications, for local and systemic drug delivery. I will outline a number of challenges of interest in particulate drug delivery.

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收藏

页码：203 / 209

页数：7

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