PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

被引：534

作者：

Shen, Yingjie ^{[1
,2
]}

Tenney, Alan P. ^{[1
,2
]}

Busch, Sarah A. ^{[3
]}

Horn, Kevin P. ^{[3
]}

Cuascut, Fernando X. ^{[3
]}

Liu, Kai ^{[4
]}

He, Zhigang ^{[4
]}

Silver, Jerry ^{[3
]}

Flanagan, John G. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

[3] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

[4] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

来源：

SCIENCE | 2009年 / 326卷 / 5952期

关键词：

TYROSINE-PHOSPHATASE-SIGMA; SPINAL-CORD-INJURY; CENTRAL-NERVOUS-SYSTEM; GLIAL SCAR; AXONAL REGENERATION; FUNCTIONAL RECOVERY; IN-VIVO; GROWTH; CNS; LAR;

D O I：

10.1126/science.1178310

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phosphatase, PTP sigma, binds with high affinity to neural CSPGs. Binding involves the chondroitin sulfate chains and a specific site on the first immunoglobulin-like domain of PTP sigma. In culture, PTP sigma(-/-) neurons show reduced inhibition by CSPG. A PTP sigma fusion protein probe can detect cognate ligands that are up-regulated specifically at neural lesion sites. After spinal cord injury, PTP sigma gene disruption enhanced the ability of axons to penetrate regions containing CSPG. These results indicate that PTP sigma can act as a receptor for CSPGs and may provide new therapeutic approaches to neural regeneration.

引用

页码：592 / 596

页数：5

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