Integrins: masters and slaves of endocytic transport

被引：409

作者：

Caswell, Patrick T. ^{[1
]}

Vadrevu, Suryakiran ^{[1
]}

Norman, Jim C. ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Canc Res UK, Glasgow G61 3BX, Lanark, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 12期

关键词：

CLATHRIN-MEDIATED ENDOCYTOSIS; REGULATING CELL-MIGRATION; ENDOTHELIAL GROWTH-FACTOR; ALPHA-5-BETA-1; INTEGRIN; CYTOPLASMIC DOMAIN; PLASMA-MEMBRANE; 3D MICROENVIRONMENTS; RECYCLING PATHWAYS; FOCAL ADHESIONS; LIPID RAFTS;

D O I：

10.1038/nrm2799

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.

引用

页码：843 / 853

页数：11

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