Synthesis and synthetic application of α-formylvinylphosphonates.: Facile synthesis of phosphono-substituted heterocyclic compounds

被引：28

作者：

Kouno, R ^{[1
]}

Tsubota, T ^{[1
]}

Okauchi, T ^{[1
]}

Minami, T ^{[1
]}

机构：

[1] Kyushu Inst Technol, Dept Appl Chem, Kitakyushu, Fukuoka 8048550, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 14期

关键词：

D O I：

10.1021/jo000149t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The beta-ethoxy-alpha-phosphonovinyl anion, generated from beta-(ethoxy)vinylphosphonate 1 and LDA, reacted with aldehydes and ketones or phenyl isocyanate to give the corresponding allylic alcohols 2a-m or 1,3-diphenyl-5-phosphonouracil 4 in good or moderate yields. Treatment of the alcohols 2a-d,g,h,j with trifluoroacetic acid led to alpha-formylvinylphosphonates 5a-d,g,h,j in excellent yields. Synthetic application of the alpha-formylvinylphosphonates 5a-d,g,h to phosphono-substituted heterocyclic compounds was studied.

引用

页码：4326 / 4332

页数：7

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