Identification and gene organization of three novel members of the IL-1 family on human chromosome 2

被引：177

作者：

Busfield, SJ ^{[1
]}

Comrack, CA ^{[1
]}

Yu, G ^{[1
]}

Chickering, TW ^{[1
]}

Smutko, JS ^{[1
]}

Zhou, H ^{[1
]}

Leiby, KR ^{[1
]}

Holmgren, LM ^{[1
]}

Gearing, DP ^{[1
]}

Pan, Y ^{[1
]}

机构：

[1] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

GENOMICS | 2000年 / 66卷 / 02期

关键词：

D O I：

10.1006/geno.2000.6184

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Members of the IL-1 family of cytokines are important in mediating inflammatory responses. The genes encoding IL-1 alpha, IL-beta, and the IL-1 receptor antagonist (IL-1Ra) are clustered within 450 kb on human chromosome 2q. By searching the EST databases and sequencing this region of chromosome 2, we have identified three novel genes that show homology to the IL-1 family, which we have named IL-1-related protein 1, 2, and 3 (IL-1RP1, IL-1RP2, and IL-1RP3). All three genes contain a signature motif common to the IL-1 family and appear to be more closely related to IL-1Ra. Similar to the intracellular form of IL-1Ra, these genes lack conventional hydrophobic signal sequences. The expression of these genes appears to be highly restricted to various epithelial cell populations. Our results demonstrate the existence of additional IL-1 gene family members within the previously defined IL-1 cluster and point to this region of chromosome 2 as an evolutionary hotspot for IL-1 gene duplication. These genes may prove to have an important role in inflammatory responses. (C) 2000 Academic Press.

引用

页码：213 / 216

页数：4

共 21 条

[1] The secretory route of the leaderless protein interleukin 1β involves exocytosis of endolysosome-related vesicles [J].