Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients

被引：148

作者：

Rezvan, Ahmadi ^{[1
]}

Christine, Dictus ^{[1
]}

Christian, Hartmann ^{[2
]}

Olga, Zuern ^{[1
]}

Lutz, Edler ^{[3
]}

Marius, Hartmann ^{[4
]}

Stephanie, Combs ^{[5
]}

Christel, Herold-Mende ^{[1
]}

Rainer, Wirtz Christian ^{[1
]}

Andreas, Unterberg ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Neurosurg, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, Clin Cooperat Unit Neuropathol, D-69120 Heidelberg, Germany

[3] German Canc Res Ctr, Inst Biostat, D-69120 Heidelberg, Germany

[4] Heidelberg Univ, Dept Neuroradiol, D-69120 Heidelberg, Germany

[5] Heidelberg Univ, Dept Radiat Oncol, D-69120 Heidelberg, Germany

来源：

ACTA NEUROCHIRURGICA | 2009年 / 151卷 / 11期

关键词：

Low-grade glioma; Extent of surgery; Survival; PROGNOSTIC-FACTORS; RANDOMIZED-TRIAL; RADIATION-THERAPY; RADIOTHERAPY; ASTROCYTOMAS; SURGERY; MANAGEMENT; EFFICACY; IMPACT; TUMOR;

D O I：

10.1007/s00701-009-0435-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The appropriate management of low-grade gliomas is still a matter of debate. So far, there are no randomized studies that analyze the impact of surgical resection on patient outcome. The value of the data obtained from the few retrospective reports available is often limited. In the present study, we performed an analysis on data of 130 adult low-grade glioma patients. Extent of the resection was evaluated in correlation to the overall survival (OS) and progression-free survival (PFS) using Cox regression multivariate analysis. Extended surgery was shown to prolong OS and PFS significantly. Re-surgery in the case of a tumor relapse has a significant impact on OS and PFS, too. In summary, we could retrospectively evaluate a large case series of well-defined low-grade gliomas patients with a long follow-up period showing that extended surgery would be the most effective therapy for low-grade glioma patients even in recurrent diseases.

引用

页码：1359 / 1365

页数：7

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