Expression of Cancer-Testis Antigens MAGE-A3/6 and NY-ESO-1 in Non-Small-Cell Lung Carcinomas and Their Relationship with Immune Cell Infiltration

被引：79

作者：

Kim, Sang Hyun ^{[1
,2
]}

Lee, Sangyull ^{[3
]}

Lee, Chang Hun ^{[1
,2
,4
]}

Lee, Min Ki ^{[5
]}

Kim, Young Dae ^{[6
]}

Shin, Dong Hoon ^{[1
,2
]}

Choi, Kyung Un ^{[1
,2
]}

Kim, Jee Yeon ^{[1
,2
]}

Park, Do Youn ^{[1
,2
]}

Sol, Mee Young ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Sch Med, Dept Pathol, Yangsan Si 626770, Gyeongsangnam D, South Korea

[2] Pusan Natl Univ, Sch Med, Med Res Inst, Yangsan Si 626770, Gyeongsangnam D, South Korea

[3] Pusan Natl Univ, Sch Med, Dept Biochem, Yangsan Si 626770, Gyeongsangnam D, South Korea

[4] Pusan Natl Univ Hosp, Dept Pathol, Pusan 602739, South Korea

[5] Pusan Natl Univ, Sch Med, Dept Internal Med, Yangsan Si 626770, Gyeongsangnam D, South Korea

[6] Pusan Natl Univ, Sch Med, Dept Thorac Surg, Yangsan Si 626770, Gyeongsangnam D, South Korea

来源：

LUNG | 2009年 / 187卷 / 06期

关键词：

Cancer-testis antigens; Dendritic cell; CD8 T lymphocyte; Non-small-cell lung carcinoma; POSITIVE DENDRITIC CELLS; CANCER/TESTIS CT ANTIGENS; CD8(+) T-CELLS; HLA-DR ANTIGEN; HEPATOCELLULAR-CARCINOMA; PROGNOSTIC-SIGNIFICANCE; ACTIVATION; TUMORS; IMMUNOGENICITY; LYMPHOCYTES;

D O I：

10.1007/s00408-009-9181-3

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Cancer-testis antigens (CTAs) are expressed only in many cancers and limited immunoprivileged sites such as the testis and placenta. Dendritic cells (DCs) and CD8+ T lymphocytes (CTLs) play roles in the immune responses to tumor growth and may affect the prognosis of cancers. This study was designed to investigate the clinicopathologic significance of CTA expression in non-small-cell lung carcinomas (NSCLCs) and its relationship with immune cells. Immunohistochemical staining to CTAs such as MAGE-A3/6 and NY-ESO-1 was performed using paraffin blocks from 132 cases of NSCLCs, including 75 cases of squamous cell carcinoma (SqCC) and 57 cases of adenocarcinoma (AdC), and the results were evaluated to correlate with tumor-infiltrating DCs and CTLs and clinicopathologic features. MAGE-A3/6 and NY-ESO-1 were expressed in 50.0% (66/132) and 18.2% (24/132) of NSCLCs, respectively. MAGE-A3/6 was expressed more frequently in SqCC than in AdC, but the expression of NY-ESO-1 showed no difference in both types. CTAs revealed a higher expression in male than in female. In advanced stage III, NY-ESO-1-positive patients showed poorer survival than NY-ESO-1-negative patients. Otherwise, the CTA expression did not correlate with clinicopathologic parameters. No relationship was found between DC and CTL infiltration in all NSCLCs. Regarding DC infiltration, the group showing negative expression to CTAs displayed an even higher number of infiltrating DCs than those showing positivity to one or the other or both CTAs. Although the aberrant expression of MAGE-A3/6 and NY-ESO-1 in NSCLC did not directly influence clinical prognostic factors, the higher expression of MAGE-A3/6 in SqCC suggests its value as a potential target for immunotherapy in this type of NSCLC. The inverse relationship between DCs and CTA expression may indicate that CTA-positive tumor cells would be akin to tumor stem cells escaping host immune response.

引用

页码：401 / 411

页数：11

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