Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose

被引：32

作者：

Galea, M.

Jelacin, N.

Bramham, K.

White, I.

机构：

[1] St Peters Hosp, Dept Anaesthesia & Intens Care, Chertsey KT16 0PZ, Surrey, England

[2] St Helier Hosp, Dept Med, Carshalton SM5 1AA, Surrey, England

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2007年 / 98卷 / 02期

关键词：

blood; haemofiltration; complications; acidosis; lactic; rhabdomyolysis; compartment syndrome; metformin;

D O I：

10.1093/bja/ael347

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril. The lactic acidosis was successfully treated with early high-volume continuous veno-venous haemofiltration. Rhabdomyolysis and lower limb compartment syndrome developed later. The patient otherwise made a good recovery. We discuss the management of severe lactic acidosis secondary to metformin overdose and the association with rhabdomyolysis.

引用

页码：213 / 215

页数：3

共 10 条

[1] Clearance of metformin by hemofiltration in overdose [J].

Barrueto, F ;

Meggs, WJ ;

Barchman, MJ .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2002, 40 (02) :177-180

[2]

Chang CT, 2002, J NEPHROL, V15, P398

[3] Survival following a metformin overdose of 63 g: A case report [J].

Gjedde, S ;

Christiansen, A ;

Pedersen, SB ;

Rungby, J .

PHARMACOLOGY & TOXICOLOGY, 2003, 93 (02) :98-99

[4] Bicarbonate haemodialysis as a treatment of metformin overdose [J].

Heaney, D ;

Majid, A ;

Junor, B .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1997, 12 (05) :1046-1047

[5] Consequences of metformin intoxication [J].

Lalau, JD ;

Mourlhon, C ;

Bergeret, A ;

Lacroix, C .

DIABETES CARE, 1998, 21 (11) :2036-2037

[6] A fatal case of metformin poisoning [J].

Nisse, P ;

Mathieu-Nolf, M ;

Deveaux, M ;

Forceville, X ;

Combes, A .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2003, 41 (07) :1035-1036

[7] Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis [J].

Panzer, U ;

Kluge, S ;

Kreymann, G ;

Wolf, G .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2004, 19 (08) :2157-2158

[8] The management of metformin overdose [J].

Teale, KFH ;

Devine, A ;

Stewart, H ;

Harper, NJH .

ANAESTHESIA, 1998, 53 (07) :698-701

[9] Acute compartment syndrome secondary to diabetic muscle infarction: case report and literature review [J].

Woolley, Sarah L. ;

Smith, David R. K. .

EUROPEAN JOURNAL OF EMERGENCY MEDICINE, 2006, 13 (02) :113-116

[10]

Yumul R, 2004, TRAUMACARE, V14, P143

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