Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor:: Potential therapeutic applications for epilepsy and obesity

被引：41

作者：

Isaac, M ^{[1
]}

Slassi, A ^{[1
]}

O'Brien, A ^{[1
]}

Edwards, L ^{[1
]}

MacLean, N ^{[1
]}

Bueschkens, D ^{[1
]}

Lee, DKH ^{[1
]}

McCallum, K ^{[1
]}

De Lannoy, I ^{[1
]}

Demchyshyn, L ^{[1
]}

Kamboj, R ^{[1
]}

机构：

[1] NPS Allelix Corp, Mississauga, ON L4V 1V7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)00141-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pyrrolo[3,2,1-ij]quinoline derivatives was synthesized, evaluated for their activity against the 5-HT2c and 5-HT2a, receptors and found to be agonists at 5-HT2c with selectivity over 5-HT2a. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：919 / 921

页数：3

共 11 条

[1] Novel agonists of 5HT(2C) receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder [J].