Differential effects of olanzapine and risperidone on cognition in schizophrenia? A saccadic eye movement study

被引：16

作者：

Broerse, A ^{[1
]}

Crawford, TJ ^{[1
]}

den Boer, JA ^{[1
]}

机构：

[1] Univ Groningen Hosp, Dept Psychiat, Sect Biol Psychiat, Grad Sch Behav & Cognit Neurosci, NL-9700 RB Groningen, Netherlands

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2002年 / 14卷 / 04期

关键词：

D O I：

10.1176/appi.neuropsych.14.4.454

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies suggest that novel antipsychotics have positive effects on certain cognitive functions in schizophrenia. The present study investigated this claim by means of saccadic paradigms, which provide a selective index of cognitive function. Thirty-three first-episode schizophrenic patients were randomly assigned to either olanzapine or risperidone treatment and compared with healthy control subjects for three saccadic paradigms. The influence of symptom profile, extrapyramidal symptoms, age, education, gender, hospitalization, and medication dose on cognitive performance was also investigated. Although the two patient groups did not differ from each other in task performance, both patient groups showed substantial problems in inhibitory control of saccades. A high level of education appeared to be protective for this impairment.

引用

页码：454 / 460

页数：7

共 24 条

[1] The role of the thalamus in schizophrenia [J].

Andreasen, NC .

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1997, 42 (01) :27-33

[2] Parsing cognition in schizophrenia using saccadic eye movements: a selective overview [J].

Broerse, A ;

Crawford, TJ ;

den Boer, JA .

NEUROPSYCHOLOGIA, 2001, 39 (07) :742-756

[3] Risperidone improves antisaccade error rates in schizophrenia [J].

Burke, JG ;

Patel, JKM ;

Morris, PK ;

Reveley, MA .

SCHIZOPHRENIA RESEARCH, 1998, 29 (1-2) :115-115

[4] SACCADIC ABNORMALITIES IN PSYCHOTIC-PATIENTS .2. THE ROLE OF NEUROLEPTIC TREATMENT [J].

CRAWFORD, TJ ;

HAEGER, B ;

KENNARD, C ;

REVELEY, MA ;

HENDERSON, L .

PSYCHOLOGICAL MEDICINE, 1995, 25 (03) :473-483

[5] SACCADIC ABNORMALITIES IN PSYCHOTIC-PATIENTS .1. NEUROLEPTIC-FREE PSYCHOTIC-PATIENTS [J].

CRAWFORD, TJ ;

HAEGER, B ;

KENNARD, C ;

REVELEY, MA ;

HENDERSON, L .

PSYCHOLOGICAL MEDICINE, 1995, 25 (03) :461-471

[6] ABNORMALITIES OF NONVISUALLY-GUIDED EYE-MOVEMENTS IN PARKINSONS-DISEASE [J].

CRAWFORD, TJ ;

HENDERSON, L ;

KENNARD, C .

BRAIN, 1989, 112 :1573-1586

[7] On the development of voluntary and reflexive components in human saccade generation [J].

Fischer, B ;

Biscaldi, M ;

Gezeck, S .

BRAIN RESEARCH, 1997, 754 (1-2) :285-297

[8]

GOLDMANRAKIC PS, 1994, J NEUROPSYCH CLIN N, V6, P348

[9]

Green MF, 1996, AM J PSYCHIAT, V153, P321

[10]

HEMSLEY DR, 1994, NEUROL PSYCHIAT BR, V2, P163

← 1 2 3 →