Light-induced helix formation

被引：27

作者：

Huang, CY

He, S

DeGrado, WF

McCafferty, DG ^{[1
]}

Gai, F

机构：

[1] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[2] Univ Penn, Johnson Res Fdn, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 43期

关键词：

D O I：

10.1021/ja028084u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study shows that incorporation of [Rub2m-OH]2+ at the N-terminus of the Fs peptide enhances its stability by∼0.15 kcal/mol through the mechanism of dipole-dipole coupling at the excited state, suggesting that photoinduced charge generation at a well-controlled and specific location provides a convenient means to trigger helix-coil transition on nanosecond or even faster time scales. Copyright © 2002 American Chemical Society.

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页码：12674 / 12675

页数：2

相关论文

共 15 条

[1] A method for photoinitating protein folding in a nondenaturing environment [J].

Hansen, KC ;

Rock, RS ;

Larsen, RW ;

Chan, SI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (46) :11567-11568

[2] Helix formation via conformation diffusion search [J].

Huang, CY ;

Getahun, Z ;

Zhu, YJ ;

Klemke, JW ;

DeGrado, WF ;

Gai, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) :2788-2793

[3] Temperature-dependent helix-coil transition of an alanine based peptide [J].

Huang, CY ;

Klemke, JW ;

Getahun, Z ;

DeGrado, WF ;

Gai, F .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (38) :9235-9238

[4] Photo-control of helix content in a short peptide [J].

Kumita, JR ;

Smart, OS ;

Woolley, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :3803-3808

[5] INTERNAL STARK-EFFECT MEASUREMENT OF THE ELECTRIC-FIELD AT THE AMINO TERMINUS OF AN ALPHA-HELIX [J].

LOCKHART, DJ ;

KIM, PS .

SCIENCE, 1992, 257 (5072) :947-951

[6] ELECTROSTATIC SCREENING OF CHARGE AND DIPOLE INTERACTIONS WITH THE HELIX BACKBONE [J].

LOCKHART, DJ ;

KIM, PS .

SCIENCE, 1993, 260 (5105) :198-202

[7] FTIR SPECTROSCOPY OF ALANINE-BASED PEPTIDES - ASSIGNMENT OF THE AMIDE I' MODES FOR RANDOM COIL AND HELIX [J].

MARTINEZ, G ;

MILLHAUSER, G .

JOURNAL OF STRUCTURAL BIOLOGY, 1995, 114 (01) :23-27

[8] SPECTROSCOPIC STUDY OF ELECTRON-TRANSFER IN A TRIFUNCTIONAL LYSINE WITH ANTHRAQUINONE AS THE ELECTRON-ACCEPTOR [J].

MECKLENBURG, SL ;

MCCAFFERTY, DG ;

SCHOONOVER, JR ;

PEEK, BM ;

ERICKSON, BW ;

MEYER, TJ .

INORGANIC CHEMISTRY, 1994, 33 (13) :2974-2983

[9] ELECTROABSORPTION (STARK-EFFECT) SPECTROSCOPY OF MONORUTHENIUM AND BIRUTHENIUM CHARGE-TRANSFER COMPLEXES - MEASUREMENTS OF CHANGES IN DIPOLE-MOMENTS AND OTHER ELECTROOPTIC PROPERTIES [J].

OH, DH ;

SANO, M ;

BOXER, SG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (18) :6880-6890

[10] STARK-EFFECT SPECTRA OF RU(DIIMINE)32+ COMPLEXES [J].

OH, DH ;

BOXER, SG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (03) :1130-1131