Disruption of the kinin B1 receptor gene affects potentiating effect of captopril on BK-induced contraction in mice stomach fundus

被引：13

作者：

Barbosa, Ana M. R. B. ^{[1
]}

Felipe, Sandra A. ^{[1
]}

Pesquero, Joao B. ^{[1
]}

Paiva, Antonio C. M. ^{[1
]}

Shimuta, Suma I. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 Sao Paulo, Brazil

来源：

PEPTIDES | 2006年 / 27卷 / 12期

基金：

巴西圣保罗研究基金会;

关键词：

kinin B-1 receptor knockout; bradykinin; angiotensin converting enzyme; inhibitor;

D O I：

10.1016/j.peptides.2006.09.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A transgenic mouse model, deficient in kinin B-1 receptor (B-1(-/-)) was used to evaluate the role of B-2 receptor in the smooth muscle stomach fundus. The results showed that the potency of bradykinin (BK) to induce contraction in the gastric tissue was maintained whereas the efficacy was markedly reduced. The angiotensin converting enzyme (ACE) inhibitor captopril potentiated BK-induced effect in wild type (WT) but not in B-1(-/-) fundus. However, ACE activity detected by the convertion of Ang I to Ang II was inhibited by captopril in both types of gastric tissues. Taking into account the hypothesis that captopril and ACE bind to the B2 receptor, we suggest that this complex was not formed in the stomach deficient in B-1 receptor. Therefore, our finding strongly support the hypothesis that in smooth muscles that constitutively express the kinin B1 and B2 receptors, an interaction between captopril and ACE, B1 and B2 receptors should occur forming a complex protein interaction for the potentiating effect of ACE on kinin receptors. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：3377 / 3382

页数：6

共 27 条

[1] Kinin B-1 and B-2 receptors in the mouse [J].

Allogho, SN ;

Gobeil, F ;

Pheng, LH ;

NguyenLe, XK ;

Neugebauer, W ;

Regoli, D .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1995, 73 (12) :1759-1764

[2] RELAXING EFFECT OF BRADYKININ ON INTESTINAL SMOOTH MUSCLE [J].

ANTONIO, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1968, 32 (01) :78-+

[3] Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function [J].

Araújo, RC ;

Mori, MA ;

Merino, VF ;

Bascands, JL ;

Schanstra, JP ;

Zollner, RL ;

Villela, CA ;

Nakaie, CR ;

Paiva, ACM ;

Pesquero, JL ;

Bader, M ;

Pesquero, JB .

BIOLOGICAL CHEMISTRY, 2006, 387 (04) :431-436

[4]

BHOOLA KD, 1992, PHARMACOL REV, V44, P1

[5] FURTHER EVIDENCE FOR THE EXISTENCE OF 2 RECEPTOR-SITES FOR BRADYKININ RESPONSIBLE FOR THE DIPHASIC EFFECT IN THE RAT ISOLATED DUODENUM [J].

BOSCHCOV, P ;

PAIVA, ACM ;

PAIVA, TB ;

SHIMUTA, SI .

BRITISH JOURNAL OF PHARMACOLOGY, 1984, 83 (02) :591-600

[6]

CABRINI D, 1909, J PHARMACOL EXP THER, V277, P299

[7] BRADYKININ-INDUCED BIPHASIC RESPONSE IN THE RAT ISOLATED STOMACH FUNDUS - FUNCTIONAL EVIDENCE FOR A NOVEL BRADYKININ RECEPTOR [J].

CALIXTO, JB ;

MEDEIROS, YS .

LIFE SCIENCES, 1992, 50 (07) :PL47-PL52

[8] Vasoactive potential of the B1 bradykinin receptor in normotension and hypertension [J].

Duka, I ;

Kintsurashvili, E ;

Gavras, I ;

Johns, C ;

Bresnahan, M ;

Gavras, H .

CIRCULATION RESEARCH, 2001, 88 (03) :275-281

[9] Kinins, receptors, kininases and inhibitors -: Where did they lead us? [J].

Erdös, EG ;

Marcic, BM .

BIOLOGICAL CHEMISTRY, 2001, 382 (01) :43-47

[10]

FERES T, 1994, BRAZ J MED BIOL RES, V27, P1911

← 1 2 3 →