The potential of resveratrol against human gliomas

被引:51
作者
Gagliano, Nicoletta [1 ]
Aldini, Giancarlo [2 ]
Colomb, Graziano [3 ]
Rossi, Ranieri [4 ]
Colomb, Roberto [3 ]
Gioia, Magda
Milzani, Aldo [3 ]
Dalle-Donne, Isabella [3 ]
机构
[1] Univ Milan, Dept Human Morphol & Biomed Sci Citta Studi, Sch Med, Extracellular Matrix Lab, I-20090 Milan, Italy
[2] Univ Milan, Dept Pharmaceut & Toxicol Chem Pietro Pratesi, I-20090 Milan, Italy
[3] Univ Milan, Dept Biol, I-20090 Milan, Italy
[4] Univ Siena, Dept Evolut Biol, I-53100 Siena, Italy
关键词
glioma; oxidative stress; resveratrol; tumour progression; NF-KAPPA-B; CANCER CHEMOPREVENTIVE ACTIVITY; INDUCED APOPTOSIS; CELL-CYCLE; MATRIX METALLOPROTEINASES; OXIDATIVE STRESS; CYCLOOXYGENASE-2; EXPRESSION; INDUCED ACTIVATION; TRANS-RESVERATROL; CYSTEINE SPARC;
D O I
10.1097/CAD.0b013e32833498f1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
There is growing interest in dietary phytochemicals as potential cancer chemopreventive agents. Resveratrol (3,4',5-trihydroxy-trans-stilbene), a naturally occurring phytoalexin that is present in grapes, red wine, berries and peanuts, has been studied extensively for its ability to interfere with multistage carcinogenesis. Resveratrol is known to have antioxidant, anti-inflammatory and anti proliferative effects on a variety of cancer cells in vitro and in various animal models. However, the effect(s) of resveratrol in vivo on humans are still controversial. This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas. Anti-Cancer Drugs 21:140-150 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:140 / 150
页数:11
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