Immunodeficiency: UNC-93B gets a toll call

被引：10

作者：

Conley, Mary Ellen ^{[1
]}

机构：

[1] Univ Tennessee, Coll Med, Dept Pediat, Memphis, TN 38103 USA

[2] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 03期

关键词：

BACILLE CALMETTE-GUERIN; KAPPA-B PATHWAY; DEFICIENCY; INFECTION; ENCEPHALITIS; INNATE; IRFS;

D O I：

10.1016/j.it.2007.01.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defects in innate immunity have moved to center stage in the past five years. This can be explained, at least in part, by the development of molecular assays and genetic tools that enable new approaches. Two recent studies using these elegant tools show that a transmembrane endoplasmic reticulum protein, UNC-93B, is essential for the normal response to signaling through the Toll-like receptors (TLRs) that respond to viral infection, TLR3, TLR7, TLR8 and TLR9.

引用

页码：99 / 101

页数：3

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