Fatal Lactic Acidosis Associated With the Use of Combination Oral Medications to Treat Reactivation of Hepatitis B

被引：23

作者：

Cohen, Stanley Martin ^{[1
]}

Levy, Ronald M.

Jovanovich, John F. ^{[2
]}

Ahn, Joseph ^{[1
]}

机构：

[1] Rush Univ, Med Ctr, Sect Hepatol, Chicago, IL 60612 USA

[2] Gilead Sci Inc, Med Sci, Foster City, CA 94404 USA

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2009年 / 43卷 / 10期

关键词：

hepatitis B; nucleoside analogs; nucleotide analogs; chemotherapy-induced reactivation; NON-HODGKINS-LYMPHOMA; VIRUS REACTIVATION; ANTIRETROVIRAL THERAPY; MITOCHONDRIAL TOXICITY; CYTOTOXIC CHEMOTHERAPY; ADEFOVIR DIPIVOXIL; NUCLEOSIDE ANALOG; RISK-FACTORS; LAMIVUDINE; INFECTION;

D O I：

10.1097/MCG.0b013e31819c3945

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Oral nucleos(t)ide analogs for the treatment of hepatitis B virus (HBV) infection are well tolerated with minimal side effects. These agents do carry it Food and Drug Administration "black box" warning about the development Of fatal lactic acidosis oil the basis of data from the human immunodeficiency virus literature. However, no previously published cases of this lethal side effect have been reported in patients undergoing HBV treatment using the Current Food and Drug Administration-approved HBV medications. We report a case of HBV reactivation after chemotherapy for leukemia, and the development of fatal lactic acidosis attributed to the Use of combination Oral HBV medications.

引用

页码：1008 / 1010

页数：3

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