Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

被引:377
作者
Simonsen, Anne [2 ]
Tooze, Sharon A. [1 ]
机构
[1] Canc Res UK, London Res Inst, London WC2A 3PX, England
[2] Univ Oslo, Inst Basic Med Sci, Dept Biochem, Fac Med, N-0317 Oslo, Norway
关键词
PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES; C-VPS COMPLEX; SACCHAROMYCES-CEREVISIAE; ENDOSOME FUNCTION; ENDOPLASMIC-RETICULUM; REGULATES AUTOPHAGY; BINDING-PROTEIN; EPSILON-COP; DEEP-ORANGE; BECLIN;
D O I
10.1083/jcb.200907014
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Autophagy or "self-eating" is a highly conserved pathway that enables cells to degrade pieces of themselves in autolysosomes to enable their survival in times of stress, including nutrient deprivation. The formation of these degradative compartments requires cytosolic proteins, some of which are autophagy specific, as well as intracellular organelles, such as the ER and Golgi, and the endosome-lysosome system. Here we discuss the cross talk between autophagy and intracellular compartments, highlighting recent exciting data about the role and regulation of the Vps34 class III phosphatidylinositol (PI) 3-kinase in autophagy.
引用
收藏
页码:773 / 782
页数:10
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