Working memory plasticity modulated by dopamine transporter genotype

被引：59

作者：

Brehmer, Yvonne ^{[1
]}

Westerberg, Helena ^{[1
]}

Bellander, Martin ^{[1
]}

Furth, Daniel ^{[1
]}

Karlsson, Sari ^{[1
]}

Backman, Lars ^{[1
]}

机构：

[1] Karolinska Inst, Aging Res Ctr, S-11330 Stockholm, Sweden

来源：

NEUROSCIENCE LETTERS | 2009年 / 467卷 / 02期

基金：

瑞典研究理事会;

关键词：

Working memory; Training; Plasticity; Dopamine transporter polymorphism; LIFE-SPAN; GENES; DAT1; ADHD; ASSOCIATION; CHILDREN;

D O I：

10.1016/j.neulet.2009.10.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received 4 weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：117 / 120

页数：4

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