Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier

被引：164

作者：

Yang, J.

Park, S. -B.

Yoon, Ho-Geun

Huh, Y. -M. ^{[1
]}

Haam, S.

机构：

[1] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120749, South Korea

[2] Yonsei Univ, Coll Med, Dept Biochem & Mol Biol, Ctr Chron Metab Dis Res, Seoul 120752, South Korea

[3] Yuhan Res Inst, Pharamceut Dev Lab, Gunpo Si 120749, Gyeonggi Do, South Korea

[4] Yonsei Univ, Coll Engn, Dept Chem Engn, Seoul 120749, South Korea

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2006年 / 324卷 / 02期

关键词：

poly epsilon-caprolactone; magnetite; emulsion; nanoparticle; magnetic drug targeting;

D O I：

10.1016/j.ijpharm.2006.06.029

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Magnetic poly epsilon-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the Size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope ITEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：185 / 190

页数：6

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