The importance of being a myoepithelial cell

被引：130

作者：

Deugnier, MA ^{[1
]}

Teulière, J ^{[1
]}

Faraldo, MM ^{[1
]}

Thiery, JP ^{[1
]}

Glukhova, MA ^{[1
]}

机构：

[1] CNRS, Inst Curie, Sect Rech, UMR 144, F-75248 Paris 05, France

来源：

BREAST CANCER RESEARCH | 2002年 / 4卷 / 06期

关键词：

breast cancer; cell differentiation; mammary gland; morphogenesis; myoepithelial cell;

D O I：

10.1186/bcr459

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mammary myoepithelial cell was named the 'Cinderella of mammary cell biology' in light of the earlier focus on the luminal cell. Mammary myoepithelial cells have recently been described as 'natural tumour suppressors'. We now need to understand more about their origin and to reconsider their place in the complex process of mammary morphogenesis. In the present review, we discuss the lineage segregation of mammary myoepithelial cells and their functions in mammary gland development. These functions include their effects on luminal cell growth and differentiation, their key role in the establishment of the polarised mammary epithelial bilayer and the control of stromal invasion in breast cancer.

引用

页码：224 / 230

页数：7

共 65 条

[1] Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells [J].

Alpaugh, ML ;

Lee, MC ;

Nguyen, M ;

Deato, M ;

Dishakjian, L ;

Barsky, SH .

EXPERIMENTAL CELL RESEARCH, 2000, 261 (01) :150-158

[2]

Anbazhagan R, 1998, J PATHOL, V184, P197, DOI 10.1002/(SICI)1096-9896(199802)184:2&lt

[3]

197::AID-PATH992&gt

[4]

3.0.CO

[5]

2-J

[6] p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast [J].

Barbareschi, M ;

Pecciarini, L ;

Cangi, MG ;

Macrì, E ;

Rizzo, A ;

Viale, G ;

Doglioni, C .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (08) :1054-1060

[7] Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages:: A new cell biological concept [J].

Böcker, W ;

Moll, R ;

Poremba, C ;

Holland, R ;

van Diest, PJ ;

Dervan, P ;

Bürger, H ;

Wai, D ;

Diallo, RI ;

Brandt, B ;

Herbst, H ;

Schmidt, A ;

Lerch, MM ;

Buchwallow, IB .

LABORATORY INVESTIGATION, 2002, 82 (06) :737-745

[8] LOCALIZATION AND QUANTIFICATION OF WNT-2 GENE-EXPRESSION IN MOUSE MAMMARY DEVELOPMENT [J].

BUHLER, TA ;

DALE, TC ;

KIEBACK, C ;

HUMPHREYS, RC ;

ROSEN, JM .

DEVELOPMENTAL BIOLOGY, 1993, 155 (01) :87-96

[9] DUCTAL MORPHOGENESIS IN THE MOUSE MAMMARY-GLAND - EVIDENCE SUPPORTING A ROLE FOR EPIDERMAL GROWTH-FACTOR [J].

COLEMAN, S ;

SILBERSTEIN, GB ;

DANIEL, CW .

DEVELOPMENTAL BIOLOGY, 1988, 127 (02) :304-315

[10]

Deugnier MA, 1999, J CELL SCI, V112, P1035

← 1 2 3 4 5 6 7 →