Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa

被引：16

作者：

Piazzi, G.

Paterini, P.

Ceccarelli, C.

Pantaleo, M. A.

Biasco, G.

机构：

[1] Univ Bologna, S Orsola Malpighi, CRBA, I-40138 Bologna, Italy

[2] Univ Bologna, S Orsola Malpighi, Dept Internal Med & Gastroenterol, Surg Pathol Unit, I-40138 Bologna, Italy

[3] Univ Bologna, S Orsola Malpighi, Dept Oncol, Inst Haematol & Med Oncol, I-40138 Bologna, Italy

来源：

BRITISH JOURNAL OF CANCER | 2006年 / 95卷 / 11期

关键词：

EGFr; phosphorylated EGFr; colorectal cancer; targeted therapy;

D O I：

10.1038/sj.bjc.6603441

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.

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收藏

页码：1525 / 1528

页数：4

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