Non-matrigel scaffolds for organoid cultures

被引：122

作者：

Kaur, Savneet ^{[1
]}

Kaur, Impreet ^{[1
]}

Rawal, Preety ^{[1
,2
]}

Tripathi, Dinesh M. ^{[1
]}

Vasudevan, Ashwini ^{[1
]}

机构：

[1] Inst Liver & Biliary Sci, Dept Mol & Cellular Med, New Delhi, India

[2] Gautam Buddha Univ, Sch Biotechnol, Greater Noida, UP, India

来源：

CANCER LETTERS | 2021年 / 504卷

关键词：

Hydrogel; Matrigel; Organoids; Scaffolds; Stem cells; 3D cultures;

D O I：

10.1016/j.canlet.2021.01.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Organoids are three-dimensional cell cultures mostly from tissue-resident or embryonic stem cells (one or multiple) on hydrogels along with defined growth factors. Currently, matrigel is the most commonly employed matrix for 3D organoid cultures. However, certain undesirable attributes of matrigel have paved the way for several other natural and synthetic hydrogel scaffolds for organoid cultures. In this review, we discuss the constraints of matrigel and describe other alternative scaffolds that have been used for organoid cultures. Given the potential of organoids in a plethora of therapeutic and pharmaceutical applications, it is indeed imperative to develop defined and customized hydrogels other than the matrigel.

引用

页码：58 / 66

页数：9

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