The pathogenetic role of HLA-B27 and its subtypes

被引：115

作者：

Khan, Muhammad Asim

Mathieu, Alessandro

Sorrentino, Rosa

Akkoc, Nurullah

机构：

[1] Case Western Reserve Univ, Metrohlth Med Ctr, Div Rheumatol, Cleveland, OH 44109 USA

[2] Univ Cagliari, Dept Med Sci, I-09042 Cagliari, Italy

[3] Univ Roma La Sapienza, Dept Cell & Dev Biol, I-00185 Rome, Italy

[4] Dokuz Eylul Univ, Sch Med, Dept Internal Med, TR-35340 Izmir, Turkey

来源：

AUTOIMMUNITY REVIEWS | 2007年 / 6卷 / 03期

关键词：

animal models; ankylosing spondylitis; HLA-B27; pathogenesis;

D O I：

10.1016/j.autrev.2006.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The strong association between HLA-B27 and ankylosing spondylitis has been known for more than 33 years, but the enigma of the pathogenetic role of the gene and its product has not yet been solved. Ongoing studies have produced evidence supporting different theories to explain this association, and structural and functional studies of HLA-B27 allele products at molecular level have provided information of broad and multidisciplinary value and disclosed new avenues leading to autoimmunity and immune disregulation. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：183 / 189

页数：7

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