The chicken NKX2.8 homeobox gene: A novel member of the NK-2 gene family

被引：18

作者：

Boettger, T ^{[1
]}

Stein, S ^{[1
]}

Kessel, M ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,D-37077 GOTTINGEN,GERMANY

来源：

DEVELOPMENT GENES AND EVOLUTION | 1997年 / 207卷 / 01期

关键词：

NK-2; homeobox; tinman; heart; branchial arch; chicken;

D O I：

10.1007/s004270050092

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have isolated the chicken homeobox gene NKX2.8, which represents a novel member of the NK-2 gene family. Besides the homeodomain, the NKX2.8 protein contains two other conserved sequences, a TN and an NK2 domain. NKX2.8 is expressed in the ventral foregut, the developing heart, in the epithelial layers of the branchial arches and in the dorsal mesocardium. Thus, its expression overlaps partially, but also differs significantly from another chicken tinman orthologue, the NKX2.5 gene. It is suggestive that NKX2.8 and NKX2.5 play a cooperative role in early heart development.

引用

页码：65 / 70

页数：6

共 14 条

[1]

BODMER R, 1993, DEVELOPMENT, V118, P719

[2]

CHARLEBOIS TS, 1990, DEVELOPMENT, V110, P417

[3] CnNK-2, an NK-2 homeobox gene, has a role in patterning the basal end of the axis in hydra [J].

Grens, A ;

Gee, L ;

Fisher, DA ;

Bode, HR .

DEVELOPMENTAL BIOLOGY, 1996, 180 (02) :473-488

[4] A SERIES OF NORMAL STAGES IN THE DEVELOPMENT OF THE CHICK EMBRYO [J].

HAMBURGER, V ;

HAMILTON, HL .

JOURNAL OF MORPHOLOGY, 1951, 88 (01) :49-&

[5] NK-2 homeobox genes and heart development [J].

Harvey, RP .

DEVELOPMENTAL BIOLOGY, 1996, 178 (02) :203-216

[6] HOMEOTIC TRANSFORMATIONS OF MURINE VERTEBRAE AND CONCOMITANT ALTERATION OF HOX CODES INDUCED BY RETINOIC ACID [J].

KESSEL, M ;

GRUSS, P .

CELL, 1991, 67 (01) :89-104

[7] CRYSTAL-STRUCTURE OF AN ENGRAILED HOMEODOMAIN-DNA COMPLEX AT 2.8-A RESOLUTION - A FRAMEWORK FOR UNDERSTANDING HOMEODOMAIN-DNA INTERACTIONS [J].

KISSINGER, CR ;

LIU, BS ;

MARTINBLANCO, E ;

KORNBERG, TB ;

PABO, CO .

CELL, 1990, 63 (03) :579-590

[8] A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm [J].

Lee, KH ;

Xu, QH ;

Breitbart, RE .

DEVELOPMENTAL BIOLOGY, 1996, 180 (02) :722-731

[9] Vertebrate heart development [J].

Lyons, GE .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (04) :454-460

[10] MYOGENIC AND MORPHOGENETIC DEFECTS IN THE HEART TUBES OF MURINE EMBRYOS LACKING THE HOMEO BOX GENE NKX2-5 [J].

LYONS, I ;

PARSONS, LM ;

HARTLEY, L ;

LI, RL ;

ANDREWS, JE ;

ROBB, L ;

HARVEY, RP .

GENES & DEVELOPMENT, 1995, 9 (13) :1654-1666

← 1 2 →