Structure and mechanism of the pepsin-like family of aspartic peptidases

被引：298

作者：

Dunn, BM ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Biochem & Mol Biol, Gainesville, FL 32610 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr010167q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Structure... A review is given of a variety of work conducted on the pepsin-like members of the aspartic endopeptidase family over the last dozen years. It is evident that the information base has expanded greatly and that new targets are available for drug discovery. It is also clear that new questions are emerging regarding the genetic relationships of these enzymes, the biosynthesis, folding, and targeting of proteins, the mechanism of activation of the different types of proenzymes, and the mechanism of catalysis.

引用

页码：4431 / 4458

页数：28

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