Biosensors for DNA sequence detection

被引：121

作者：

Vercoutere, W

Akeson, M

机构：

[1] NASA, Ames Res Ctr, Natl Space Grant Fdn, Bone Signaling Lab, Moffett Field, CA 94035 USA

[2] Univ Calif Santa Cruz, Howard Hughes Med Inst, Dept Chem, Santa Cruz, CA 95064 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 06期

关键词：

D O I：

10.1016/S1367-5931(02)00395-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA biosensors are being developed as alternatives to conventional DNA microarrays. These devices couple signal transduction directly to sequence recognition. Some of the most sensitive and functional technologies use fibre optics or electrochemical sensors in combination with DNA hybridization. In a shift from sequence recognition by hybridization, two emerging single-molecule techniques read sequence composition using zero-mode waveguides or electrical impedance in nanoscale pores.

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收藏

页码：816 / 822

页数：7

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