FREALIGN: High-resolution refinement of single particle structures

被引：372

作者：

Grigorieff, Nikolaus ^{[1
]}

机构：

[1] Brandeis Univ, Rosenstiel Basic Med Sci Res Ctr, Howard Hughes Med Inst, Dept Biochem, Waltham, MA 02254 USA

来源：

JOURNAL OF STRUCTURAL BIOLOGY | 2007年 / 157卷 / 01期

关键词：

image processing; electron microscopy; protein structure; FREALIGN;

D O I：

10.1016/j.jsb.2006.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The refinement of three-dimensional reconstructions and correction for the contrast transfer function of the microscope are important steps in the determination of macromolecular structures by single particle electron microscopy. The algorithms implemented in the computer program FREALIGN are optimized to perform these tasks efficiently. A general overview and details on how to use FREALIGN are provided. The program is free and available for download on the author's web page. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：117 / 125

页数：9

共 31 条

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