In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

被引：75

作者：

Jones-Brando, Lorraine

D'Angelo, John

Posner, Gary H.

Yolken, Robert

机构：

[1] Johns Hopkins Univ, Sch Med, Stanley Div Dev Neurovirol, Dept Pediat, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Malaria Res Inst, Baltimore, MD 21287 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 12期

关键词：

D O I：

10.1128/AAC.00793-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

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收藏

页码：4206 / 4208

页数：3

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