An Analytical Solution to the Kinetics of Breakable Filament Assembly

被引：879

作者：

Knowles, Tuomas P. J. ^{[1
,2
]}

Waudby, Christopher A. ^{[3
]}

Devlin, Glyn L. ^{[3
]}

Cohen, Samuel I. A. ^{[3
]}

Aguzzi, Adriano ^{[4
]}

Vendruscolo, Michele ^{[3
]}

Terentjev, Eugene M. ^{[2
]}

Welland, Mark E. ^{[1
]}

Dobson, Christopher M. ^{[3
]}

机构：

[1] Univ Cambridge, Nanosci Ctr, Cambridge CB3 0FF, England

[2] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England

[3] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[4] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland

来源：

SCIENCE | 2009年 / 326卷 / 5959期

基金：

英国工程与自然科学研究理事会;

关键词：

AMYLOID FORMATION; AGGREGATION; NUCLEATION; POLYMERIZATION; MECHANISM; TIME;

D O I：

10.1126/science.1178250

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present an analytical treatment of a set of coupled kinetic equations that governs the self-assembly of filamentous molecular structures. Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events. Our results further reveal a range of general features of the growth kinetics of fragmenting filamentous structures, including the existence of generic scaling laws that provide mechanistic information in contexts ranging from in vitro amyloid growth to the in vivo development of mammalian prion diseases.

引用

页码：1533 / 1537

页数：5

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