The Stressed CNS: When Glucocorticoids Aggravate Inflammation

被引：276

作者：

Sorrells, Shawn F. ^{[1
]}

Caso, Javier R. ^{[2
,3
]}

Munhoz, Carolina D. ^{[4
]}

Sapolsky, Robert M. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Neurosurg, Stanford, CA 94305 USA

[4] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo, Brazil

来源：

NEURON | 2009年 / 64卷 / 01期

关键词：

FACTOR-KAPPA-B; PROTEIN-KINASE PHOSPHATASE-1; OXIDE SYNTHASE EXPRESSION; RESTRAINT STRESS; ACTIVATOR PROTEIN-1; CYTOKINE RESPONSES; CEREBRAL-ISCHEMIA; IMMUNE-RESPONSES; BRAIN CORTEX; RECEPTOR;

D O I：

10.1016/j.neuron.2009.09.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glucocorticoids (GCs) are hormones released during the stress response that are well known for their immunosuppressive and anti-inflammatory properties; however, recent advances have uncovered situations wherein they have effects in the opposite direction. The CNS is a particularly interesting example, both because of its unique immune environment, and because GCs affect immune responses differently in different brain regions. In this minireview we discuss the contexts wherein GCs increase CNS inflammation and point out directions for future investigation.

引用

页码：33 / 39

页数：7

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