Making the Cut: The Chemical Biology of Cytokinesis

被引：34

作者：

Atilla-Gokcumen, G. Ekin ^{[1
,2
]}

Castoreno, Adam B. ^{[1
,2
]}

Sasse, Sofia ^{[1
,2
,3
]}

Eggert, Ulrike S. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[3] Univ Munster, D-4400 Munster, Germany

来源：

ACS CHEMICAL BIOLOGY | 2010年 / 5卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Actin; Cleavage furrow/contractile ring; Cytokinesis; Metabolites; Midzone; Myosin; Phosphatidylinositol 4,5-bisphosphate (PIP2); Small molecule probes; Tubulin; MYOSIN LIGHT-CHAIN; CLEAVAGE FURROW; CELL-DIVISION; FISSION YEAST; ANIMAL CYTOKINESIS; ZEBRAFISH EMBRYOS; AURORA-B; DROSOPHILA SPERMATOCYTES; SIGNALING MOLECULES; MEMBRANE DOMAINS;

D O I：

10.1021/cb900256m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cytokinesis is the last step in the cell cycle, where daughter cells finally separate. It is precisely regulated in both time and space to ensure that each daughter cell receives an equal share of DNA and other cellular materials. Chemical biology approaches have been used very successfully to study the mechanism of cytokinesis. In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis.

引用

页码：79 / 90

页数：12

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