The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival

被引：246

作者：

Carson, Monica J. ^{[1
]}

Thrash, J. Cameron ^{[1
]}

Walter, Barbara ^{[1
]}

机构：

[1] Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA

来源：

CLINICAL NEUROSCIENCE RESEARCH | 2006年 / 6卷 / 05期

关键词：

microglia; TREM; antigen-presentation;

D O I：

10.1016/j.cnr.2006.09.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuroinflammation is a complex integration of the responses of all cells present within the CNS, including the neurons, macroglia, microglia and the infiltrating leukocytes. The initiating insult, environmental factors, genetic background and age/past experiences all combine to modulate the integrated response of this complex neuroinflammatory circuit. Here, we explore how these factors interact to lead to either neuroprotective versus neurotoxic inflammatory responses. We specifically focus on microglia and astrocytic regulation of autoreactive T cell responses. (C) 2006 Association for Research in Nervous and Mental Disease. Published by Elsevier B.V. All rights reserved.

引用

页码：237 / 245

页数：9

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