Sedation with "non-sedating'' antihistamines: four prescription-event monitoring studies in general practice

被引:105
作者
Mann, RD
Pearce, GL
Dunn, N
Shakir, S
机构
[1] Univ Southampton, Southampton, Hants, England
[2] Drug Safety Res Unit, Southampton SO31 1AA, Hants, England
关键词
D O I
10.1136/bmj.320.7243.1184
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives To investigate the frequency with which sedation was reported in post-marketing surveillance studies of four second generation antihistamines: loratadine, cetirizine, fexofenadine, and acrivastine. Design Prescription-event monitoring studies. Setting Prescriptions were obtained for each cohort in the immediate post-marketing period. Subjects Event data were obtained for a total of 43 363 patients. Main outcome measure Reporting of sedation or drowsiness. Results The adds ratios (adjusted for age and sex) for the incidence of sedation were 0.63 (95% confidence interval 0.36 to 1.11; P = 0.1) for fexofenadine; 2.79 (1.69 to 4.58; p < 0.0001) for acrivastine, and 3.53 (2.07 to 5.42; P < 0.0001) for cetirizine compared with loratadine. No increased risk of accident or injury it as evident with any of the four drugs. Conclusions Although the risk of sedation was low with all four drugs, fexofenadine and loratadine may be more appropriate for people working in safety critical jobs.
引用
收藏
页码:1184 / 1186
页数:3
相关论文
共 9 条
[1]  
Gonzalez MA, 1998, INT J CLIN PHARM TH, V36, P292
[2]   Prescription-event monitoring - recent progress and future horizons [J].
Mann, RD .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 46 (03) :195-201
[3]  
MANN RD, 1984, MODERN DRUG USE, P16
[4]  
Markham A, 1998, DRUGS, V55, P269, DOI 10.2165/00003495-199855020-00012
[5]  
Nightingale CH, 1996, PHARMACOTHERAPY, V16, P905
[6]   Sedative effects of antihistamines: Safety, performance, learning, and quality of life [J].
Nolen, TM .
CLINICAL THERAPEUTICS, 1997, 19 (01) :39-55
[7]   Qi lengthening and life-threatening arrhythmias associated with fexofenadine [J].
Pinto, YM ;
van Gelder, IC ;
Heeringa, M ;
Crijns, HJGM .
LANCET, 1999, 353 (9157) :980-980
[8]   Second-generation antihistamines - A comparative review [J].
Slater, JW ;
Zechnich, AD ;
Haxby, DG .
DRUGS, 1999, 57 (01) :31-47
[9]   The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England [J].
Wilton, LV ;
Pearce, GL ;
Martin, RM ;
Mackay, FJ ;
Mann, RD .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1998, 105 (08) :882-889