Exercise therapy in Type 2 diabetes

被引:95
作者
Praet, Stephan F. E. [1 ]
van Loon, Luc J. C. [2 ]
机构
[1] Erasmus Univ, Med Ctr, Dept Rehabil Med, NL-3000 CA Rotterdam, Netherlands
[2] Maastricht Univ Med Ctr, Dept Human Movement Sci, Fac Hlth Med & Life Sci, Maastricht, Netherlands
关键词
Exercise prescription; Pathophysiology; Type; 2; diabetes; Treatment adherence; Complications; Safety; GENOME-WIDE ASSOCIATION; LIFE-STYLE MODIFICATION; SILENT-MYOCARDIAL-ISCHEMIA; HEPATIC INSULIN-RESISTANCE; GLYCATION END-PRODUCTS; CORONARY-HEART-DISEASE; ALPHA-LIPOIC ACID; POSTPRANDIAL GLUCOSE-HOMEOSTASIS; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; IMPAIRED MITOCHONDRIAL ACTIVITY;
D O I
10.1007/s00592-009-0129-0
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Structured exercise is considered an important cornerstone to achieve good glycemic control and improve cardiovascular risk profile in Type 2 diabetes. Current clinical guidelines acknowledge the therapeutic strength of exercise intervention. This paper reviews the wide pathophysiological problems associated with Type 2 diabetes and discusses the benefits of exercise therapy on phenotype characteristics, glycemic control and cardiovascular risk profile in Type 2 diabetes patients. Based on the currently available literature, it is concluded that Type 2 diabetes patients should be stimulated to participate in specifically designed exercise intervention programs. More attention should be paid to cardiovascular and musculoskeletal deconditioning as well as motivational factors to improve long-term treatment adherence and clinical efficacy. More clinical research is warranted to establish the efficacy of exercise intervention in a more differentiated approach for Type 2 diabetes subpopulations within different stages of the disease and various levels of co-morbidity.
引用
收藏
页码:263 / 278
页数:16
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