共 24 条
A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks
被引:15
作者:
Baker, Kathryn D.
[1
]
Edwards, Thomas M.
[1
]
Rickard, Nikki S.
[1
]
机构:
[1] Monash Univ, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia
关键词:
Ryanodine receptor;
Calcium;
Intracellular calcium stores;
4-Chloro-m-cresol;
Discriminative avoidance learning;
Memory;
Chick;
CALCIUM STORES;
SYNAPTIC PLASTICITY;
RELEASE;
4-CHLORO-M-CRESOL;
MOBILIZATION;
HIPPOCAMPUS;
CHANNELS;
MICE;
D O I:
10.1016/j.bbr.2009.08.026
中图分类号:
B84 [心理学];
C [社会科学总论];
Q98 [人类学];
学科分类号:
03 ;
0303 ;
030303 ;
04 ;
0402 ;
摘要:
Young chicks were trained on a weakly reinforced variant of a single-trial discrimination avoidance task which typically fails to consolidate the long-term memory stage. The ryanodine receptor (RyR) agonist 4-chloro-m-cresol (500 mu M, i.c.) persistently promoted high retention until at least 24 h post-training when administered between the time of training and 20 min post-training. The consolidation of the long-term memory stage by RyR activation implicates intracellular calcium release in triggering long-term memory. (C) 2009 Elsevier B.V. All rights reserved.
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页码:143 / 146
页数:4
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