A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks

被引:15
作者
Baker, Kathryn D. [1 ]
Edwards, Thomas M. [1 ]
Rickard, Nikki S. [1 ]
机构
[1] Monash Univ, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia
关键词
Ryanodine receptor; Calcium; Intracellular calcium stores; 4-Chloro-m-cresol; Discriminative avoidance learning; Memory; Chick; CALCIUM STORES; SYNAPTIC PLASTICITY; RELEASE; 4-CHLORO-M-CRESOL; MOBILIZATION; HIPPOCAMPUS; CHANNELS; MICE;
D O I
10.1016/j.bbr.2009.08.026
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Young chicks were trained on a weakly reinforced variant of a single-trial discrimination avoidance task which typically fails to consolidate the long-term memory stage. The ryanodine receptor (RyR) agonist 4-chloro-m-cresol (500 mu M, i.c.) persistently promoted high retention until at least 24 h post-training when administered between the time of training and 20 min post-training. The consolidation of the long-term memory stage by RyR activation implicates intracellular calcium release in triggering long-term memory. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:143 / 146
页数:4
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