Functional significance of oligomerization of G-protein-coupled receptors

被引：101

作者：

Salahpour, A

Angers, S

Bouvier, M ^{[1
]}

机构：

[1] Univ Montreal, Dept Biochem, Montreal, PQ H3C 3J7, Canada

[2] Univ Montreal, Grp Rech Syst Nerveux Autonome, Montreal, PQ H3C 3J7, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 05期

关键词：

D O I：

10.1016/S1043-2760(00)00260-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In contrast to other families of cell surface receptors for which dimerization is an integral part of the activation process, G-protein-coupled receptors (GPCRs) were thought, until recently, to function as monomeric units. However, a growing body of evidence indicates that GPCRs could exist and be active as oligomeric complexes. Because they are major pharmacological targets, their existence as homo- or heterodimers could have important implications for the development and screening of new drugs.

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页码：163 / 168

页数：6

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