The chemical UV-filter 3-benzylidene camphor causes an oestrogenic effect in an in vivo fish assay

被引：48

作者：

Holbech, H ^{[1
]}

Norum, U ^{[1
]}

Korsgaard, B ^{[1
]}

Bjerregaard, P ^{[1
]}

机构：

[1] Univ So Denmark, Inst Biol, DK-5230 Odense M, Denmark

来源：

PHARMACOLOGY & TOXICOLOGY | 2002年 / 91卷 / 04期

关键词：

D O I：

10.1034/j.1600-0773.2002.t01-3-910403.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chemical UV-filters are used in sun protection products and various kinds of cosmetics. The lipophilic chemical UV-filter 3-benzylidene camphor was investigated for its capability to cause vitellogenin induction, possibly via oestrogen receptor binding, in a well-established in vivo fish assay (juvenile rainbow trout, Oncorhynchus mykiss, vitellogenin ELISA). A clear relationship was demonstrated between the dose of injected 3-benzylidene camphor and the concentration of plasma vitellogenin with a 10(5)-times induction from 68 mg 3-benzylidene camphor /kg/injection and above compared to the control vitellogenin level. The relationship between the injected dose of 3-benzylidene camphor and the percent of responding fish (vitellogenin) was evaluated by logistic regression analysis and effective dose-values (ED-values) were determined. ED10, ED50 and ED90 of 3-benzylidene camphor after 6 days (2 injections) were 6.4, 16 and 26 mg/kg/ injection, respectively. These ED-values place 3-benzylidene camphor among the more potent xenooestrogens discovered to date and necessitates investigations on the distribution, concentration, persistence and bioaccumulation of 3-benzylidene camphor and other UV-filters in nature.

引用

页码：204 / 208

页数：5

共 24 条

[1] Effects of xenoestrogen treatment on zona radiata protein and vitellogenin expression in Atlantic salmon (Salmo salar) [J].