Endometriosis is sustained by tumour necrosis factor-α

被引：47

作者：

Bullimore, DW

机构：

[1] Barnsley Dist. Gen. Hospital Trust, Barnsley S75 2EP, Gawber Road

来源：

MEDICAL HYPOTHESES | 2003年 / 60卷 / 01期

关键词：

D O I：

10.1016/S0306-9877(02)00336-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Endometriosis is a common gynaecological disorder causing pain, infertility, and emotional distress. Evidence presented here suggests that abnormal production of tumour necrosis factor-alpha (TNF-alpha) is required for the establishment and maintenance of endometriosis and also is responsible for the associated infertility through its effect on sperm motility and function and oocyte development. Infliximab, which blocks TNF-a function, could be used in the treatment of endometriosis to reverse the above effects. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：84 / 88

页数：5

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