Inflammation and wasting in chronic kidney disease: Partners in crime

被引：71

作者：

Avesani, C. M. ^{[1
]}

Carrero, J. J. ^{[1
]}

Axelsson, J. ^{[1
]}

Qureshi, A. R. ^{[1
]}

Lindholm, B. ^{[1
]}

Stenvinkel, P. ^{[1
]}

机构：

[1] Karolinska Inst, Div Baxter Novum & Renal Med, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

来源：

KIDNEY INTERNATIONAL | 2006年 / 70卷

关键词：

inflammation; cytokines; muscle wasting; sarcopenia; chronic kidney disease;

D O I：

10.1038/sj.ki.5001969

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Protein energy malnutrition (PEM) is often present in patients with chronic kidney disease with or without ongoing renal replacement therapy. Muscle wasting (sarcopenia) is one of the hallmarks of PEM in these patients and recent studies have reported a link between sarcopenia and inflammation. The low-grade inflammation often observed in end-stage renal disease (ESRD) can lead to sarcopenia through an increase in protein catabolism, a decrease in protein syntheses or both. The activation of the ATP-ubiquitin-proteasome pathway, insulin resistance, hypermetabolism, and decreased appetite are all plausible pathophysiological pathyways whereby inflammation can contribute to sarcopenia and PEM. In the present review we discuss these interactions between inflammation and wasting in ESRD patients and explore putative pathways involved in this condition.

引用

页码：S8 / S13

页数：6

共 39 条

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