Magnetic resonance spectroscopy and cognitive function in healthy elderly men

被引:63
作者
Ferguson, KJ
MacLullich, AMJ
Marshall, I
Deary, IJ
Starr, JM
Seckl, JR
Wardlaw, JM
机构
[1] Univ Edinburgh, Western Gen Hosp, Geriatr Med Unit, Edinburgh EH3 9EW, Midlothian, Scotland
[2] Univ Edinburgh, Brain Imaging Res Ctr Scotland, Edinburgh EH3 9EW, Midlothian, Scotland
[3] Univ Edinburgh, Mol Med Ctr, Edinburgh EH3 9EW, Midlothian, Scotland
[4] Univ Edinburgh, Dept Psychol, Edinburgh EH3 9EW, Midlothian, Scotland
[5] Univ Edinburgh, Dept Clin Neurosci, Edinburgh EH3 9EW, Midlothian, Scotland
关键词
cognition; creatine; H-1-MRS; memory; spectroscopy;
D O I
10.1093/brain/awf278
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Subtle cognitive decrements in older people are important in terms of the associated morbidity and as a risk factor for dementia. However, their pathophysiological basis is poorly understood. Proton magnetic resonance spectroscopy (H-1-MRS) may provide the means to investigate early changes in brain metabolite concentrations. We examined the relationships between N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) metabolite ratios in a voxel in the parietal cortex and cognitive function in 88 healthy, non-demented, unmedicated men aged 65-70 years. We also used linear regression to give a value for each metabolite adjusted for the levels of the other two metabolites. Both NAA/Cr and Cho/Cr ratios correlated positively with tests of verbal memory and a verbal memory factor (e.g. NAA/Cr and Logical Memory: r = 0.24, P < 0.05). Cho/Cr ratios also correlated positively with tests of visual memory (e.g. visual reproduction: r = 0.21, P < 0.05). Adjusted Cr levels correlated negatively and significantly with tests of verbal memory and the Verbal Memory Factor. The regression analysis suggested that Cr levels better explained the correlations between NAA/Cr and Cho/Cr ratios and cognitive variables than NAA or Cho levels. These results suggest that in healthy men aged 65-70 years, metabolite levels relate to cognitive performance. Rising Cr levels may be an early marker of cognitive decline.
引用
收藏
页码:2743 / 2749
页数:7
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