Cell-Based Therapy for Ischemic Heart Disease: A Clinical Update

被引：49

作者：

Herrmann, Jeremy L.

Abarbanell, Aaron M.

Weil, Brent R.

Wang, Yue

Wang, Meijing

Tan, Jiangning

Meldrum, Daniel R.

机构：

[1] Indiana Univ, Sch Med, Dept Surg, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN USA

[3] Indiana Univ, Sch Med, Ctr Immunobiol, Indianapolis, IN USA

来源：

ANNALS OF THORACIC SURGERY | 2009年 / 88卷 / 05期

关键词：

MESENCHYMAL STEM-CELLS; ACUTE MYOCARDIAL-INFARCTION; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; STROMAL CELLS; MONONUCLEAR-CELLS; INTRACORONARY INJECTION; SKELETAL MYOBLASTS; PERIPHERAL-BLOOD;

D O I：

10.1016/j.athoracsur.2009.05.079

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Progenitor cell therapy is a promising treatment for ischemic heart disease. Early clinical trials of autologous bone marrow-derived progenitor cell therapy for acute and chronic myocardial ischemia showed modest functional improvements after cell delivery; however, the duration of these benefits remains unclear. Ongoing investigations continue to enhance our understanding of the mechanisms by which progenitor and stem cells function and how their survival and cardioprotective abilities can be improved. This review discusses: (1) relevant progenitor and stem cells in myocardial regenerative therapy, (2) routes of cell delivery to ischemic myocardium, (3) clinical trials investigating bone marrow-derived progenitor cell therapy for myocardial ischemia, and (4) future directions of the field. (Ann Thorac Surg 2009; 88: 1714-22) (C) 2009 by The Society of Thoracic Surgeons

引用

收藏

页码：1714 / 1722

页数：9

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