Stem cells, stress, metabolism and cancer: a drama in two Octs

被引：129

作者：

Kang, Jinsuk ^{[1
]}

Shakya, Arvind ^{[1
]}

Tantin, Dean ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84112 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 10期

关键词：

TRANSCRIPTION FACTOR OCT-4; DNA-BINDING; POU DOMAIN; EMBRYONIC-DEVELOPMENT; COACTIVATOR OBF-1; GENE-EXPRESSION; OCTAMER FACTORS; SELF-RENEWAL; PLURIPOTENCY; PROMOTER;

D O I：

10.1016/j.tibs.2009.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

It is a classic story of two related transcription factors. Oct4 is a potent regulator of pluripotency during early mammalian embryonic development, and is notable for its ability to convert adult somatic cells to pluripotency. The widely expressed Oct1 protein shares significant homology with Oct4, binds to the same sequences, regulates common target genes, and shares common modes of upstream regulation, including the ability to respond to cellular stress. Both proteins are also associated with malignancy, yet Oct1 cannot substitute for Oct4 in the generation of pluripotency. The molecular underpinnings of these phenomena are emerging, as are the consequences for adult stem cells and cancer, and thereby hangs a tale.

引用

页码：491 / 499

页数：9

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