Solid-state characterization and dissolution characteristics of gliclazide-beta-cyclodextrin inclusion complexes

Solid complexes between gliclazide and beta-cyclodextrin (beta-CD) were prepared by kneading, coprecipitation, neutralization, co-grinding and spray-drying. Characterization of glicrazide-beta-CD inclusion complexes was performed using X-ray diffractometry and cross polarizing/magic angle spinning C-13-nuclear magnetic resonance spectroscopy. These techniques have clearly demonstrated the existence of solid-state inclusion compound formation. The complexes, obtained by neutralization and spray-drying methods, showed enhanced dissolution rates of gliclazide. (C) 1997 Elsevier Science B.V.