Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detectimz rapid diagnostic tests

被引：35

作者：

Lee, Nelson

Baker, Joanne

Be, David

McCarthy, James

Cheng, Qin ^{[1
]}

机构：

[1] Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Brisbane, Qld, Australia

[2] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

[3] Univ Queensland, Queensland Inst Med Res, Joint Program, Australian Ctr Int & Trop Hlth, Brisbane, Qld, Australia

[4] WHO, Reg Off Western Pacific, Manila, Philippines

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 12期

关键词：

EXPERT MICROSCOPY; MALARIA; SEQUENCE;

D O I：

10.1128/JCM.01611-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.

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收藏

页码：4547 / 4549

页数：3

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