Prediction of N-terminal protein sorting signals

被引:111
作者
Claros, MG
Brunak, S
vonHeijne, G
机构
[1] TECH UNIV DENMARK,DEPT CHEM,CTR BIOL SEQUENCE ANAL,DK-2800 LYNGBY,DENMARK
[2] STOCKHOLM UNIV,ARRHENIUS LAB,DEPT BIOCHEM,S-10691 STOCKHOLM,SWEDEN
关键词
D O I
10.1016/S0959-440X(97)80057-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
Recently, neural networks have been applied to a widening range of problems in molecular biology. An area particularly suited to neural-network methods is the identification of protein sorting signals and the prediction of their cleavage sites, as these functional units are encoded by local, linear sequences of amino acids rather than global 3D structures. (C) Current Biology Ltd.
引用
收藏
页码:394 / 398
页数:5
相关论文
共 42 条
[1]
ARRIGO P, 1991, COMPUT APPL BIOSCI, V7, P353
[2]
Bishop C. M., 1995, Neural networks for pattern recognition
[3]
CHADONIA JM, 1996, PROTEIN SCI, V5, P768
[4]
CLAROS MG, 1995, COMPUT APPL BIOSCI, V11, P441
[5]
Computational method to predict mitochondrially imported proteins and their targeting sequences [J].
Claros, MG ;
Vincens, P .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 241 (03) :779-786
[6]
LIMITATIONS TO IN-VIVO IMPORT OF HYDROPHOBIC PROTEINS INTO YEAST MITOCHONDRIA - THE CASE OF A CYTOPLASMICALLY SYNTHESIZED APOCYTOCHROME-B [J].
CLAROS, MG ;
PEREA, J ;
SHU, YM ;
SAMATEY, FA ;
POPOT, JL ;
JACQ, C .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 228 (03) :762-771
[7]
COLGROVE RC, 1990, THESIS U CALIFORNIA
[8]
COMPUTER-ASSISTED PREDICTIONS OF SIGNAL PEPTIDASE PROCESSING SITES [J].
FOLZ, RJ ;
GORDON, JI .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (02) :870-877
[9]
CLEAVAGE-SITE MOTIFS IN MITOCHONDRIAL TARGETING PEPTIDES [J].
GAVEL, Y ;
VONHEIJNE, G .
PROTEIN ENGINEERING, 1990, 4 (01) :33-37
[10]
A CONSERVED CLEAVAGE-SITE MOTIF IN CHLOROPLAST TRANSIT PEPTIDES [J].
GAVEL, Y ;
VONHEIJNE, G .
FEBS LETTERS, 1990, 261 (02) :455-458