Synaptic plasticity and dynamic modulation of the portsynaptic membrane

被引：514

作者：

Lüscher, C

Nicoll, RA

Malenka, RC

Muller, D

机构：

[1] Univ Geneva, Dept Physiol, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Dept Neurol, CH-1211 Geneva, Switzerland

[3] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[5] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Friend Pritzker Lab, Palo Alto, CA 94304 USA

[6] Univ Geneva, CMU, APSIC, Dept Pharmacol, CH-1211 Geneva 4, Switzerland

来源：

NATURE NEUROSCIENCE | 2000年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/75714

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The biochemical composition of the postsynaptic membrane and the structure of dendritic spines may be rapidly modulated by synaptic activity. Here we review these findings, discuss their implications for long-term potentiation (LTP) and long-term depression (LTD) and propose a model of sequentially occurring expression mechanisms.

引用

收藏

页码：545 / 550

页数：6

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