Breast Cancer Molecular Subtypes in Patients With Locally Advanced Disease: Impact on Prognosis, Patterns of Recurrence, and Response to Therapy

被引：97

作者：

Huber, Kathryn E. ^{[1
,2
,4
]}

Carey, Lisa A. ^{[3
]}

Wazer, David E. ^{[2
,4
]}

机构：

[1] Tufts Med Ctr, Dept Radiat Oncol, Boston, MA 02111 USA

[2] Brown Univ, Sch Med, Rhode Isl Hosp, Providence, RI 02912 USA

[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Div Hematol Oncol, Dept Med, Chapel Hill, NC 27599 USA

[4] Tufts Univ, Sch Med, Dept Radiat Oncol, Boston, MA 02111 USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2009年 / 19卷 / 04期

关键词：

PATHOLOGICAL COMPLETE RESPONSE; GENE-EXPRESSION PROFILES; PROGESTERONE-RECEPTOR; ESTROGEN-RECEPTOR; NEOADJUVANT CHEMOTHERAPY; PREOPERATIVE CHEMOTHERAPY; TUMOR SUBTYPES; ADJUVANT CHEMOTHERAPY; DISTANT RECURRENCE; HER2; STATUS;

D O I：

10.1016/j.semradonc.2009.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene expression profiling has led to the discovery of 4 distinct molecular subtypes of breast cancer: luminal A, luminal B, basal like, and HER2 enriched. Investigation of these subtypes in women with breast cancer has given insight into the heterogeneous biology and outcomes in patients with locally advanced disease. These subtypes have been found to be predictors for survival, response to systemic therapy, and locoregional recurrence. This review discusses the biology of locally advanced breast cancer and the available data on how molecular subtype may provide information regarding response to treatment and prognosis of women with locally advanced breast cancer. © 2009 Elsevier Inc. All rights reserved.

引用

页码：204 / 210

页数：7

共 56 条

[1] Descriptive analysis of estrogen receptor (ER)negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype - A population-based study from the California Cancer Registry [J].

Bauer, Katrina R. ;

Brown, Monica ;

Cress, Rosemary D. ;

Parise, Carol A. ;

Caggiano, Vincent .

CANCER, 2007, 109 (09) :1721-1728

[2] Gene expression profiling identifies molecular subtypes of inflammatory breast cancer [J].

Bertucci, F ;

Finetti, P ;

Rougemont, J ;

Charafe-Jauffret, E ;

Cervera, N ;

Tarpin, C ;

Nguyen, C ;

Xerri, L ;

Houlgatte, M ;

Jacquemier, J ;

Viens, P ;

Birnbaum, D .

CANCER RESEARCH, 2005, 65 (06) :2170-2178

[3] Her2/neu-positive disease does not increase risk of locoregional recurrence for patients treated with neoadjuvant doxorubicin-based chemotherapy, mastectomy, and radiotherapy [J].

Buchholz, TA ;

Huang, EH ;

Berry, D ;

Pusztai, L ;

Strom, EA ;

McNeese, MD ;

Perkins, GH ;

Schechter, NR ;

Kuerer, HM ;

Buzdar, AU ;

Valero, V ;

Hunt, KK ;

Hortobagyi, GN ;

Sahin, AA .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 59 (05) :1337-1342

[4] Screening interval breast cancers: Mammographic features and prognostic factors [J].

Burrell, HC ;

Sibbering, DM ;

Wilson, ARM ;

Pinder, SE ;

Evans, AJ ;

Yeoman, LJ ;

Elston, CW ;

Ellis, IO ;

Blamey, RW ;

Robertson, JFR .

RADIOLOGY, 1996, 199 (03) :811-817

[5] The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes [J].

Carey, Lisa A. ;

Dees, E. Claire ;

Sawyer, Lynda ;

Gatti, Lisa ;

Moore, Dominic T. ;

Collichio, Frances ;

Ollila, David W. ;

Sartor, Carolyn I. ;

Graham, Mark L. ;

Perou, Charles M. .

CLINICAL CANCER RESEARCH, 2007, 13 (08) :2329-2334

[6] Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study [J].

Carey, Lisa A. ;

Perou, Charles M. ;

Livasy, Chad A. ;

Dressler, Lynn G. ;

Cowan, David ;

Conway, Kathleen ;

Karaca, Gamze ;

Troester, Melissa A. ;

Tse, Chiu Kit ;

Edmiston, Sharon ;

Deming, Sandra L. ;

Geradts, Joseph ;

Cheang, Maggie C. U. ;

Nielsen, Torsten O. ;

Moorman, Patricia G. ;

Earp, H. Shelton ;

Millikan, Robert C. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (21) :2492-2502

[7]

Chang S, 1998, CANCER, V82, P2366

[8] Expression of ER, PgR, HER1, HER2, and response: a study of preoperative chemotherapy [J].

Colleoni, M. ;

Viale, G. ;

Zahrieh, D. ;

Bottiglieri, L. ;

Gelber, R. D. ;

Veronesi, P. ;

Balduzzi, A. ;

Torrisi, R. ;

Luini, A. ;

Intra, M. ;

Dellapasqua, S. ;

Cardillo, A. ;

Ghisini, R. ;

Peruzzotti, G. ;

Goldhirsch, A. .

ANNALS OF ONCOLOGY, 2008, 19 (03) :465-472

[9] Basal breast cancer molecular subtype predicts for lower incidence of axillary lymph node metastases in primary breast cancer [J].

Crabb, Simon J. ;

Cheang, Maggie C. U. ;

Leung, Samuel ;

Immonen, Taina ;

Nielsen, Torsten O. ;

Huntsman, David D. ;

Bajdik, Chris D. ;

Chia, Stephen K. .

CLINICAL BREAST CANCER, 2008, 8 (03) :249-256

[10] Triple-negative breast cancer: Clinical features and patterns of recurrence [J].

Dent, Rebecca ;

Trudeau, Maureen ;

Pritchard, Kathleen I. ;

Hanna, Wedad M. ;

Kahn, Harriet K. ;

Sawka, Carol A. ;

Lickley, Lavina A. ;

Rawlinson, Ellen ;

Sun, Ping ;

Narod, Steven A. .

CLINICAL CANCER RESEARCH, 2007, 13 (15) :4429-4434

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