Ligand-protein interactions in nuclear receptors of hormones

被引：88

作者：

Egea, PF ^{[1
]}

Klaholz, BP ^{[1
]}

Moras, D ^{[1
]}

机构：

[1] ULP, CNRS,INSERM, Inst Genet & Biol Mol & Cellulaire, Lab Biol & Genom Struct, F-67404 Illkirch, France

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

nuclear receptor; ligand binding domain; transcriptional regulation; ligand-protein interaction; selectivity; molecular recognition;

D O I：

10.1016/S0014-5793(00)01672-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear hormone receptors are transcription factors regulated by lipophilic ligands, These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V, All rights reserved.

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页码：62 / 67

页数：6

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